The study of the molecular mechanism of sex-related psychiatric disease

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790308
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokushima (2010); The University of Tokyo (2009)
• Principal Investigator: MATSUMOTO Takahiro The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70447374)
• Project Period (FY): 2009 – 2010
• Keywords: うつ病 / 性ホルモン

Research Abstract

To study the role of sex hormones in life, we generated triple receptors (AR and ER a/b) knockout (TKO) mice. TKO male mice were born healthy but exhibited increased anxiety-like behavior with lowered post-synaptic serotonin-1A receptor in the forebrain. These data provide genetic evidence that sex steroid hormones are dispensable for the viability, but exert an anxiolytic effect via serotonin-1A receptor in males.

Research Products

• [Journal Article] DNA demethylation in hormone-induced transcriptional derepression. (2009)
  • Author(s): Kim M., Kondo T., Takada I., Youn M., Yamamoto Y., Takahashi S., Matsumoto T., (他13名).
  • Journal Title: Nature 461 Pages: 1007-1012
  • Peer Reviewed
• [Journal Article] Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). (2009)
  • Author(s): Yoshimura K., Kitagawa H., Fujiki R., Tanabe M., Takezawa S., Takada I., Yamaoka I., Yonezawa M., Kondo T., Furutani Y., Yagi H., Yoshinaga S., Masuda T., Fukuda T., Yamamoto Y., Ebihara K., Li DY., Matsuoka R., Takeuchi JK., Matsumoto T., Kato S.
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 9280-9285
  • Peer Reviewed
• [Journal Article] Co-activation of ERb by a gonadotropin-induced cofactor GIOT-4. (2009)
  • Author(s): Kouzu-Fujita M., Mezaki Y., Sawatsubashi S., Matsumoto, T., (他5名).
  • Journal Title: Mol Cell Biol 29 Pages: 83-92
  • Peer Reviewed
• [Journal Article] TSPY represses the activity of the androgen receptor in androgen-dependent testicular germ cell tumors.
  • Author(s): Akimoto C, et al., (他13名 Matsumoto T.13番目)
  • Journal Title: Proc Natl Acad Sci USA in press
  • Peer Reviewed
• [Presentation] Receptors Triple Knockout Mice to Evaluate Sex Steroid Hormones Actions. (2010)
  • Author(s): Matsumoto T.Androgen, Estrogen
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-28
• [Book] 現代栄養学を理解するための分子生物学 (2010)
  • Author(s): 松本高広
  • Total Pages: 70-74
  • Publisher: 入門光生館
• [Remarks] ホームページ等