2010 Fiscal Year Final Research Report
Analysis of the molecular mechanisms of constitutive activation of NFκB and its target genes involved in tumorigenesis in the malignant breast cancer.
| Project/Area Number |
21790310
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAGUCHI Noritaka The University of Tokyo, 医科学研究所, 助教 (80399469)
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| Project Period (FY) |
2009 – 2010
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| Keywords | シグナル伝達 |
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| Research Abstract |
The transcription factor NFκB is constitutively activated in malignant breast cancer. In the present study, we analyzed its target genes and molecular mechanisms leading to its activation. As a result, we found that NFκB induces expression of genes involved in cell proliferation and invasion/metastasis in the breast cancer. We also found that expression of NIK, one of NFκB activators, is up-regulated in the cancer. I expect that these results support development of novel therapies against the breast cancer.
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