2010 Fiscal Year Final Research Report
Molecular mechanism of serum amyloid signaling in lung metastasis
| Project/Area Number |
21790330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TOMITA Takeshi Tokyo Women's Medical University, 医学部, 助教 (20302242)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子腫瘍学 |
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| Research Abstract |
In tumor metastasis, primary tumor secretes cytokines to stimulate remote organs to induce a pre-metastatic phase, which facilitates tumor cells migration. This project revealed that Clara cell, located only in terminal bronchioles, functions as a control tower of serum amyloid A3 cascade, a culprit of the pre-metastatic phase formation, by using animal model, organ culture, and cell culture techniques.
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