2011 Fiscal Year Final Research Report
The regulation of bone formation by epigenetic factor MeCP2
| Project/Area Number |
21790340
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human genetics
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| Research Institution | Saga University |
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Principal Investigator |
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| Research Collaborator |
KOMORI Toshihisa 長崎大学, 大学院・医・歯薬学総合研究科, 教授 (00252677)
KISHINO Tatsuya 長崎大学, 先導生命科学研究支援センター, 准教授 (70315232)
MIYAZAKI Toshihiro 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10174161)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞・組織 / 発生・分化 |
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| Research Abstract |
Mutations in the MeCP2 gene are a cause of Rett syndrome. One of feature of Rett syndrome is mental retardation by progressive neurologic developmental disorder. Although it is also known that osteopenia often occurs, the mechanism is unknown. In this study, it was investigated the role of MeCP2 in the bone formation using MeCP2 null femurs. The results of the analysis showed that MeCP2 was not involved in the born formation. The cause of osteopenia in Rett syndrome may be movement problem by neurologic developmental disorder.
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Author(s)
Al-Dhaheri M, Wu J, Skliris GP, Li J, Higashimoto K, Wang Y, White KP, Lambert P, Zhu Y, Murphy L, Xu W
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Journal Title
Cancer Res
Volume: 71(6)
Pages: 2118-2128
Peer Reviewed
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[Journal Article] Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome
Author(s)
Higashimoto K, Nakabayashi K, Yatsuki H, Yoshinaga H, Jozaki K, Okada J, Watanabe Y, Aoki A, Shiozaki A, Saito S, Koide K, Mukai T, Hata K, Soejima H
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Journal Title
Am J Med Genet Part A
Volume: (in press)
Peer Reviewed
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[Presentation] Histone H3 Lys36 methylation by Ash1l triggers a regulatory cascade of the chromatin reprogramming that counteracts Polycomb silencing2011
Author(s)
Miyazaki H, Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
Organizer
第34回日本分子生物学会
Place of Presentation
横浜
Year and Date
20111213-16
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[Presentation] Role of Ash1l for transcriptional pause release2010
Author(s)
Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
Organizer
第33回日本分子生物学会年会
Place of Presentation
神戸
Year and Date
20101207-10
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[Presentation] A role of histone methylation by ASH1L in the establishment of transcriptional memory2010
Author(s)
Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
Organizer
Cold Spring Harbor Conferences Asia(Epigenetics, Chromatin & Transcription)
Place of Presentation
China
Year and Date
20100517-21
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[Presentation] Histone methylation by mammalian Ash1l facilitates induction of Hox genes in response to retinoic acid, thereby contributes to acquisition of proper identities of cervical vertebrae2009
Author(s)
Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
Organizer
第32回日本分子生物学会年会
Place of Presentation
横浜
Year and Date
20091209-12
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[Presentation] Histone methylation by mammalian Ash1l facilitates induction of Hox genes in response to retinoic acid, thereby contributes to acquisition of proper identities of cervical vertebrae2009
Author(s)
Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
Organizer
Cold Spring Harbor Meeting 2009 Mechanism of Eukaryotic Transcription
Place of Presentation
New York, United States
Year and Date
20090825-29
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