• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

The regulation of bone formation by epigenetic factor MeCP2

Research Project

  • PDF
Project/Area Number 21790340
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human genetics
Research InstitutionSaga University

Principal Investigator

HIGASHIMOTO Ken  佐賀大学, 医学部, 助教 (30346887)

Research Collaborator KOMORI Toshihisa  長崎大学, 大学院・医・歯薬学総合研究科, 教授 (00252677)
KISHINO Tatsuya  長崎大学, 先導生命科学研究支援センター, 准教授 (70315232)
MIYAZAKI Toshihiro  長崎大学, 大学院・医歯薬学総合研究科, 助教 (10174161)
Project Period (FY) 2009 – 2011
Keywords細胞・組織 / 発生・分化
Research Abstract

Mutations in the MeCP2 gene are a cause of Rett syndrome. One of feature of Rett syndrome is mental retardation by progressive neurologic developmental disorder. Although it is also known that osteopenia often occurs, the mechanism is unknown. In this study, it was investigated the role of MeCP2 in the bone formation using MeCP2 null femurs. The results of the analysis showed that MeCP2 was not involved in the born formation. The cause of osteopenia in Rett syndrome may be movement problem by neurologic developmental disorder.

  • Research Products

    (26 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (19 results) Book (1 results) Remarks (1 results)

  • [Journal Article] CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells2011

    • Author(s)
      Al-Dhaheri M, Wu J, Skliris GP, Li J, Higashimoto K, Wang Y, White KP, Lambert P, Zhu Y, Murphy L, Xu W
    • Journal Title

      Cancer Res

      Volume: 71(6) Pages: 2118-2128

    • Peer Reviewed
  • [Journal Article] Beckwith-Wiedemann syndrome with placental chorangioma due to H19-DMR hypermethylation : A Case Report2011

    • Author(s)
      Aoki A, Shiozaki A, Sameshima A, Higashimoto K, Soejima H, Saito S
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37(12) Pages: 1872-1876

    • Peer Reviewed
  • [Journal Article] Acute megakaryocytic leukemia(AMKL, FAB ; M7) with Beckwith-Wiedemann syndrome2010

    • Author(s)
      Yamamoto S, Toyama D, Yatsuki H, Higashimoto K, Soejima H, Isoyama K
    • Journal Title

      Pediatr Blood Cancer

      Volume: 55(4) Pages: 733-735

    • Peer Reviewed
  • [Journal Article] Antisense transcription occurs at the promoter of a mouse imprinted gene, Commd1, on the repressed paternal allele2009

    • Author(s)
      Joh K, Yatsuki H, Higashimoto K, Mukai T, Soejima H
    • Journal Title

      J Biochem

      Volume: 146(6) Pages: 771-774

    • Peer Reviewed
  • [Journal Article] Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome

    • Author(s)
      Higashimoto K, Nakabayashi K, Yatsuki H, Yoshinaga H, Jozaki K, Okada J, Watanabe Y, Aoki A, Shiozaki A, Saito S, Koide K, Mukai T, Hata K, Soejima H
    • Journal Title

      Am J Med Genet Part A

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome2011

    • Author(s)
      Soejima H, Nakabayashi K, Yatsuki H, Jozaki K, Hata K, Higashimoto K
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20111213-16
  • [Presentation] Histone H3 Lys36 methylation by Ash1l triggers a regulatory cascade of the chromatin reprogramming that counteracts Polycomb silencing2011

    • Author(s)
      Miyazaki H, Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      20111213-16
  • [Presentation] 本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム解析. 180超例の解析により明らかとなった本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム変異2011

    • Author(s)
      副島英伸、城崎幸介、八木ひとみ、前田寿幸、大塚泰史、東元健
    • Organizer
      日本人類遺伝学会第56回大会・第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張
    • Year and Date
      20111109-12
  • [Presentation] Beckwith-Wiedemann症候群に間葉性異形成胎盤を合併し、両者のインプリンティング異常に乖離を呈した1例2011

    • Author(s)
      三好潤也、岡島翠、松尾雄児、坂口勲、大場隆、片渕秀隆、東元健、副島英伸
    • Organizer
      第19回日本胎盤学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20110930-1001
  • [Presentation] Acquisition of aberrant hypermethylation after implantation induces discordant hypermethylation at H19-DMR between bodies and placentas in Beckwith-Wiedemann syndrome patients2011

    • Author(s)
      Soejima H, Nakabayashi K, Yatsuki H, Jozaki K, Hata K, Higashimoto K
    • Organizer
      Idibell Cancer Conferences on Imprinting and Beyond ;" Mono-allelic expression in Health and Disease
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      20110921-23
  • [Presentation] Beckwith-Wiedemann症候群に間葉性異形成胎盤を合併し、両者のインプリンティング異常に乖離を呈した1例2011

    • Author(s)
      三好潤也、坂口勲、大場隆、片渕秀隆、副島英伸、東元健
    • Organizer
      遺伝医学合同学術集会
    • Place of Presentation
      京都
    • Year and Date
      20110616-19
  • [Presentation] 本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム解析2011

    • Author(s)
      副島英伸、城崎幸介、八木ひとみ、前田寿幸、大塚泰史、東元健
    • Organizer
      遺伝医学合同学術集会
    • Place of Presentation
      京都
    • Year and Date
      20110616-19
  • [Presentation] p57KIP2(KIP2)の遺伝子変異を認めたBeckwith-Wiedemann症候群(BWS)の1例2011

    • Author(s)
      岡田純一郎、東元健、八木ひとみ、芳野信、副島英伸、渡邊順子
    • Organizer
      第34回日本小児遺伝学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-11
  • [Presentation] Role of Ash1l for transcriptional pause release2010

    • Author(s)
      Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      20101207-10
  • [Presentation] Clinical features and genome/ epigenome analyses of Japanese patients with Beckwith-Wiedemann syndrome32010

    • Author(s)
      Yoshinaga H, Higashimoto K, Yatsuki H, Maeda T, Ohtsuka Y, Jozaki K, Nakabayashi K, Hata K, Yoshiura KI, Soejima H
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      20101207-10
  • [Presentation] 本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム解析2010

    • Author(s)
      副島英伸、吉永北斗、東元健、八木ひとみ、前田寿幸、大塚泰史、中林一彦、秦健一郎、吉浦孝一郎
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      埼玉
    • Year and Date
      20100930-1001
  • [Presentation] インプリンティング疾患Beckwith-Wiedemann症候群本邦例の臨床像とゲノム・エピゲノム解析2010

    • Author(s)
      副島英伸、東元健
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      20100922-24
  • [Presentation] 本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム解析2010

    • Author(s)
      吉永北斗、東元健、八木ひとみ、中林一彦、秦健一郎、吉浦孝一郎、副島英伸
    • Organizer
      第4回日本エピジェネティクス研究会年会
    • Place of Presentation
      鳥取
    • Year and Date
      20100528-29
  • [Presentation] A role of histone methylation by ASH1L in the establishment of transcriptional memory2010

    • Author(s)
      Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      Cold Spring Harbor Conferences Asia(Epigenetics, Chromatin & Transcription)
    • Place of Presentation
      China
    • Year and Date
      20100517-21
  • [Presentation] H19-DMRのメチル化インプリントは正常発生過程で変化しうる2009

    • Author(s)
      東元健、八木ひとみ、岡田純一郎、渡邊順子、副島英伸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20091209-12
  • [Presentation] Histone methylation by mammalian Ash1l facilitates induction of Hox genes in response to retinoic acid, thereby contributes to acquisition of proper identities of cervical vertebrae2009

    • Author(s)
      Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20091209-12
  • [Presentation] H19-DMRのメチル化インプリントは正常発生過程で変化しうる2009

    • Author(s)
      東元健、八木ひとみ、岡田純一郎、渡邊順子、副島英伸
    • Organizer
      第54回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      20090923-26
  • [Presentation] Histone methylation by mammalian Ash1l facilitates induction of Hox genes in response to retinoic acid, thereby contributes to acquisition of proper identities of cervical vertebrae2009

    • Author(s)
      Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      Cold Spring Harbor Meeting 2009 Mechanism of Eukaryotic Transcription
    • Place of Presentation
      New York, United States
    • Year and Date
      20090825-29
  • [Presentation] Beckwith-Wiedemann症候群の遺伝子診断2009

    • Author(s)
      西久保敏也、田中一郎、八木ひとみ、東元健、副島英伸、高橋幸博
    • Organizer
      第32回日本小児遺伝学会学術総会
    • Place of Presentation
      奈良
    • Year and Date
      2009-04-16
  • [Book] Beckwith-Wiedemann症候群、小児科・小児疾患における臨床遺伝学の進歩2009

    • Author(s)
      東元健、副島英伸
    • Total Pages
      1046-1052
    • Publisher
      金原出版
  • [Remarks]

    • URL

      http://www.biomol.med.saga-u.ac.jp/mbg/index.htm

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi