2010 Fiscal Year Final Research Report

Design and implementation of a novel mapping technique for single-nucleotide polymorphism genotypes using Textile Plot

Research Project

Project/Area Number	21790342
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Human genetics
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	KUMASAKA Natsuhiko The Institute of Physical and Chemical Research, 統計解析研究チーム, 研究員 (80525527)
Project Period (FY)	2009 – 2010
Keywords	Data Visualization / 鎖不平衡 / 集団構造 / JAVA / ゲノムワイド関連解析 / Hardy-Weinberg平衡 / ハプロタイプ / 自然選択
Research Abstract	Textile Plot is a novel visualization technique and multivariate data analysis tool in statistics. We applied it to single-nucleotide polymorphism genotype data to develop a novel mapping technique of linkage disequilibrium, selection footprints and disease genes. We provided a population genetic perspective of the plot along with a software environment implemented in JAVA language. We also performed disease gene mappings in an association study of chronic hepatitis B and a comparative study of Crohn's disease and ulcerative colitis in Japanese.