2010 Fiscal Year Final Research Report
Molecular pathology of the mechanism of the invasion and metastasis of cholangiocarcinoma-From the aspects of epithelial-mesenchymal transition
| Project/Area Number |
21790346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
SATO Yasunori Kanazawa University, 医学系, 講師 (30324073)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 人体病理学 / 肝臓 / 胆管癌 / 上皮・間葉変換 |
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| Research Abstract |
Epithelial-mesenchymal transition (EMT) is an important mechanism behind the initiation of cancer invasion and metastasis. This study was performed to clarify the involvement of EMT in the progression of cholangiocarcinoma. Studies using cholangiocarcinoma cell lines and surgically resected specimens of cholangiocarcinoma demonstrated that EMT induced by transforming growth factor-β1/Snail activation was closely associated with the aggressive growth of cholangiocarcinoma, resulting in a poor prognosis.
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