2011 Fiscal Year Final Research Report
Expression of adenosine receptor in thyroid carcinomas
| Project/Area Number |
21790348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
NAKAZAWA Tadao 山梨大学, 医学工学総合研究部, 助教 (10345704)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 甲状腺癌 / アデノシンレセプター / 分子病理学的解析 |
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| Research Abstract |
Overexpression of adenosine receptors have recently been identified in several human cancers. The purpose of this study is to examine expression of adenosine receptor and its molecular analysis in thyroid tumors. Compared with normal thyroid tissues and benign tumors(follicular adenomas), expression of adenosine receptor 1(ADRA1) was up-regulated in thyroid carcinomas. Furthermore, this observation increased tumor cell growth and invasion in vitro. These result may suggest the adenosinergic system as a potential pharmacological target in thyroid cancer therapeutics
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