2010 Fiscal Year Final Research Report
Characterization of malignant lymphoma from viewpoint of cancer stem cells
| Project/Area Number |
21790350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Osaka University |
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Principal Investigator |
IKEDA Junichiro Osaka University, 医学系研究科, 助教 (20379176)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 癌 / 悪性リンパ腫 / 腫瘍幹細胞 / 病理学 |
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| Research Abstract |
To identify cancer stem cells in malignant lymphoma, it is necessary that cells sorted as a candidate of cancer stem cells were injected into NOD/SCID mice. In Hodgkin lymphoma cell lines, concentration of intracellular reactive oxygen species was at a low level in a portion of single-nucleated small sized (S) cells. When cultured in methylcellulose or inoculated into NOD/SCID mice, the colony number and tumor size were larger in S than in multinucleated large-sized cells.
These findings suggest that small-sized cells might play an important role in tumorigenesis of Hodgkin lymphoma.
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