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2010 Fiscal Year Final Research Report

Identification of novel tumor progression genes from SAGE/CAST methods and their diagnostic applications

Research Project

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Project/Area Number 21790353
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionHiroshima University

Principal Investigator

SENTANI Kazuhiro  Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (30508164)

Project Period (FY) 2009 – 2010
Keywords診断病理学
Research Abstract

Several discrete steps can be discerned in the biological cascades of tumor progression, and several molecules involved in their processes had been reported in gastric cancer (GC). In the present study, we searched for novel genes associated with tumor progression, based on the data of comprehensive gene expression methods. MMP7 and lamininγ2 were associated with tumor progression in GC. In contrast, connexin 30 expression reduced during tumor progression, and is a novel differentiation marker mediating the biological behavior of intestinal phenotype GC. Furthermore, claudin-18 expression correlates with poor survival in patients with CRC and is associated with the gastric phenotype.

  • Research Products

    (31 results)

All 2011 2010 2009 Other

All Journal Article (15 results) (of which Peer Reviewed: 13 results) Presentation (13 results) Book (2 results) Remarks (1 results)

  • [Journal Article] トランスレーショナルリサーチに向けた病理学的研究-消化管がんの新規診断マーカー・治療標的の同定2011

    • Author(s)
      大上直秀、仙谷和弘、坂本直也、安井弥
    • Journal Title

      日本薬理学会誌ミニレビュー「トランスレーショナルリサーチ」 137(3)

      Pages: 146-149

  • [Journal Article] 専門医のためのアトラス2010

    • Author(s)
      仙谷和弘、若松雄太、安井弥
    • Journal Title

      胃癌原発巣と転移巣の組織像胃がんperspective 3(4)

      Pages: 256-261

  • [Journal Article] Upregulation of connexin 30 in intestinal phenotype gastric cancer and its reduction during tumor progression.2010

    • Author(s)
      Sentani K, Oue N, Sakamoto N, Anami K, Naito Y, Aoyagi K, Sasaki H, Yasui W
    • Journal Title

      Pathobiology 77(5)

      Pages: 241-248

    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of colorectal cancer with gastric phenotype : claudin-18 is associated with poor prognosis.2010

    • Author(s)
      Matsuda M, Sentani K, Noguchi T, Hinoi T, Okajima M, Matsusaki K, Sakamoto N, Anami K, Naito Y, Oue N, Yasui W
    • Journal Title

      Pathol Int 60(10)

      Pages: 673-680

    • Peer Reviewed
  • [Journal Article] Immunostaining ofgastric cancer with neuroendocrine differentiation : Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, somatostatin and pancreatic polypeptide.2010

    • Author(s)
      Sentani K, Oue N, Noguchi T, Sakamoto N, Matsusaki K, Yasui W
    • Journal Title

      Pathol Int 60(4)

      Pages: 291-297

    • Peer Reviewed
  • [Journal Article] Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap : expression of DSC2 in gastric cancer with intestinal phenotype.2010

    • Author(s)
      Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Hinoi T, Okajima M, Graff JM, Yasui W
    • Journal Title

      J Pathol 221(3)

      Pages: 275-284

    • Peer Reviewed
  • [Journal Article] Serial analysis of gene expression of esophageal squamous cell carcinoma : ADAMTS16 is upregulated in esophageal squamous cell carcinoma.2010

    • Author(s)
      Sakamoto N, Oue N, Noguchi T, Sentani K, Anami K, Sanada Y, Yoshida K, Yasui W
    • Journal Title

      Cancer Sci 101(4)

      Pages: 1038-1044

    • Peer Reviewed
  • [Journal Article] Olfactomedin (GW112, hGC-1) is an independent prognostic marker for survival in patients with colorectal cancer.2010

    • Author(s)
      Seko N, Oue N, Noguchi T, Sentani K, Sakamoto N, Hinoi T, Okajima M, Yasui W
    • Journal Title

      Exp Ther Med 1(1)

      Pages: 73-78

    • Peer Reviewed
  • [Journal Article] Serum olfactomedin (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients.2009

    • Author(s)
      Oue N, Sentani K, Noguchi T, Ohara S, Sakamoto N, Hayashi T, Anami K, Motoshita J, Ito M, Tanaka S, Yoshida K, Yasui W
    • Journal Title

      Int J Cancer 125(10)

      Pages: 2383-2392

    • Peer Reviewed
  • [Journal Article] Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors.2009

    • Author(s)
      Oue N, Sentani K, Sakamoto N, Motoshita J, Nishisaka T, Fukuhara T, Matsuura H, Sasaki H, Nakachi K, Yasui W
    • Journal Title

      Int J Cancer 124(5)

      Pages: 1112-1121

    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of Reg IV in urogenital organs : Frequent expression of Reg IV in prostate cancer and potential utility as serum tumor marker.2009

    • Author(s)
      Hayashi T, Matsubara A, Ohara S, Mita K, Hasegawa Y, Usui T, Arihiro K, Norimura S, Sentani K, Oue N, Yasui W
    • Journal Title

      Oncol Rep 21(1)

      Pages: 95-100

    • Peer Reviewed
  • [Journal Article] Transcriptome dissection of gastric cancer : Identification of novel diagnostic and therapeutic targets from pathology specimens.2009

    • Author(s)
      Yasui W, Oue N, Sentani K, Sakamoto N, Motoshita J
    • Journal Title

      Pathol Int 59(3)

      Pages: 121-136

    • Peer Reviewed
  • [Journal Article] h-Prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma.2009

    • Author(s)
      Noguchi T, Oue N, Wada S, Sentani K, Sakamoto N, Kikuchi A, Yasui W
    • Journal Title

      Ann Surg Oncol 16(5)

      Pages: 1390-1396

    • Peer Reviewed
  • [Journal Article] Primary mammary mucinous cystadenocarcinoma : cytological and histological findings.

    • Author(s)
      Sentani K, Tashiro T, Uraoka N, Aosaki Y, Yano S, Takaeko F, Yasui W
    • Journal Title

      Diagn Cytopathol in press

    • Peer Reviewed
  • [Journal Article] Molecular pathology of gastric cancer : Research and practice (Review article).

    • Author(s)
      Yasui W, Sentani K, Sakamoto N, Anami K, Oue N
    • Journal Title

      Path Res Pract in press

    • Peer Reviewed
  • [Presentation] 胃型粘液形質と関連するclaudin-18の大腸癌での臨床病理学的意義と種々の分子との相関.2010

    • Author(s)
      仙谷和弘、大上直秀、阿南勝宏、坂本直也、安井弥
    • Organizer
      第21回日本消化器癌発生学会総会
    • Place of Presentation
      軽井沢
    • Year and Date
      20101118-20101119
  • [Presentation] 大腸癌におけるclaudin-18の臨床病理学的意義:種々の分子との相関.2010

    • Author(s)
      仙谷和弘、松田美穂、内藤寛、坂本直也、大上直秀、安井弥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      20100922-20100924
  • [Presentation] Immunohistochemical analysis of colorectal cancer with gastric phenotype : claudin-18 is associated with poor prognosis.2010

    • Author(s)
      Sentani K, Matsuda M, Anami K, Sakamoto N, Oue N, Yasui W
    • Organizer
      The 198th Scientific Meeting of the Pathological Society of Great Britain & Ireland
    • Place of Presentation
      St Andrews (Scotland), UK
    • Year and Date
      20100629-20100701
  • [Presentation] 遺伝子発現プロファイルで同定したHOXA10の胃癌腸型形質との関連2010

    • Author(s)
      仙谷和弘、大上直秀、坂本直也、安井弥
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      20100427-20100429
  • [Presentation] 網羅的遺伝子発現解析で同定されたHOXA10の腸型胃癌における高発現2010

    • Author(s)
      仙谷和弘、大上直秀、坂本直也、阿南勝宏、安井弥
    • Organizer
      第82回日本胃癌学会総会
    • Place of Presentation
      新潟
    • Year and Date
      20100303-20100305
  • [Presentation] Mammary mucinous cystadenocarcinoma with ductal carcinoma in situ.2010

    • Author(s)
      Sentani K, Uraoka N, Yasui W
    • Organizer
      The 20th International Symposium of the Hiroshima Cancer Seminar "Recent Progress in Carcinogenesis, Progression and Therapy of Breast Cancer"
    • Place of Presentation
      Hiroshima (Japan)
    • Year and Date
      2010-10-31
  • [Presentation] 消化器癌の基礎と臨床:胃癌-2:遺伝子発現プロファイリングの比較から同定されたHOXA10の腸型胃癌としての意義2009

    • Author(s)
      仙谷和弘、大上直秀、松田美穂、高見北斗、坂本直也、青柳一彦、佐々木博己、安井弥
    • Organizer
      第20回日本消化器癌発生学会総会 ワークショップ(4)-2
    • Place of Presentation
      広島
    • Year and Date
      20091126-20091127
  • [Presentation] 胃癌遺伝子発現プロファイルによって同定されたHOXA 10と腸型形質との関連2009

    • Author(s)
      仙谷和弘、大上直秀、坂本直也、青柳一彦、佐々木博己、安井弥
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20091001-20091003
  • [Presentation] 胃型形質を示す大腸癌におけるclaudin-18の発現と臨床病理学的検討2009

    • Author(s)
      仙谷和弘、松田美穂、大上直秀、坂本直也、林哲太郎、安井弥
    • Organizer
      第18回日本がん転移学会学術集会・総会
    • Place of Presentation
      旭川
    • Year and Date
      20090723-20090724
  • [Presentation] Usefulness of Reg IV and claudin-18 immunostaining in the diagnosis of gastrointestinal signet ring cell carcinoma 8th International Gastric Cancer Congress2009

    • Author(s)
      Sentani K, Oue N, Anami K, Yasui W
    • Organizer
      Krakow (Poland)
    • Year and Date
      20090610-20090613
  • [Presentation] 遺伝子発現プロファイルで同定されたHOXA 10の胃癌における解析2009

    • Author(s)
      仙谷和弘、大上直秀、安井弥
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      20090501-20090503
  • [Presentation] 胃癌におけるRegと種々の神経内分泌ホルモン発現との関連2009

    • Author(s)
      仙谷和弘、大上直秀、安井弥
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      20090501-20090503
  • [Presentation] 胃型粘液形質と関連するclaudin-18の大腸癌予後不良マーカーとしての意義2009

    • Author(s)
      仙谷和弘、松田美穂、高見北斗、若松雄太、坂本直也、大上直秀、安井弥
    • Organizer
      第29回日本分子腫瘍マーカー研究会
    • Place of Presentation
      横浜
    • Year and Date
      2009-09-30
  • [Book] 病理・病態生理(遺伝子変異.飯田三雄・編)(新しい診断と治療のABC 14胃癌改訂第2版)2010

    • Author(s)
      仙谷和弘、安井弥
    • Total Pages
      52-58
    • Publisher
      最新医学社、大阪
  • [Book] Histological and serological tumor markers of gastric cancer.Histological and serological tumor markers and their clinical usefulness in cancers, ed.2009

    • Author(s)
      Yasui W, Sentani K, Sakamoto N, Motoshita J, Oue N.
    • Total Pages
      93-111
    • Publisher
      Dan Hellberg, Nova Science Publishers, New York
  • [Remarks] ホームページ等

    • URL

      http://home.hiroshima-u.ac.jp/byori1/

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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