2010 Fiscal Year Final Research Report
CAST analysis of gastric cancer with gastric and intestinal phenotype
| Project/Area Number |
21790354
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
OUE Naohide Hiroshima University, 大学院・医歯薬学総合研究科, 講師 (60346484)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 腫瘍 / 胃癌 / 形質発現 / 膜蛋白質 / DSC2 / TSPAN8 |
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| Research Abstract |
Genes expressed only in cancer tissue, and especially on the cell membrane, will be good therapeutic targets. To identify genes that encode transmembrane proteins present in gastric cancer, we generated CAST libraries from three gastric cancer cell lines (MKN-1, MKN-28, and HSC-57) and normal stomach. By sequencing 7200 colonies, we identified DSC2 and TSPAN8 as a gastric cancer-specific genes. Our results provide a list of genes that have high potential as a therapeutic target for gastric cancer.
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