2011 Fiscal Year Final Research Report
Molecular-biological analysis and differential diagnosis in epithelioid sarcoma and malignant rhabdoid tumor
| Project/Area Number |
21790356
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 悪性ラブドイド腫瘍 / 類上皮肉腫 / SMARCB1/INI1 |
|---|
| Research Abstract |
Epithelioid sarcoma(ES) and malignant rhabdoid tumor(MRT) are suggested to be distinct tumor entities with respect to the microRNA profiles. Meanwhile, pediatric undifferentiated sarcoma with loss of SMARCB1/INI1 protein expression, morphologically resembling malignant lymphoma, may have the same spectrum as MRT. Evaluation of glypican 3(GPC3) immunoexpression may be a useful diagnostic tool to distinguish ES from MRT. It is suggested that MRTs with glypican 3 overexpression may become a new target of GPC3 immunotherapy.
|
Research Products
(17 results)
