2011 Fiscal Year Final Research Report
Molecular-biological analysis and differential diagnosis in epithelioid sarcoma and malignant rhabdoid tumor
| Project/Area Number |
21790356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 悪性ラブドイド腫瘍 / 類上皮肉腫 / SMARCB1/INI1 |
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| Research Abstract |
Epithelioid sarcoma(ES) and malignant rhabdoid tumor(MRT) are suggested to be distinct tumor entities with respect to the microRNA profiles. Meanwhile, pediatric undifferentiated sarcoma with loss of SMARCB1/INI1 protein expression, morphologically resembling malignant lymphoma, may have the same spectrum as MRT. Evaluation of glypican 3(GPC3) immunoexpression may be a useful diagnostic tool to distinguish ES from MRT. It is suggested that MRTs with glypican 3 overexpression may become a new target of GPC3 immunotherapy.
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