2011 Fiscal Year Final Research Report
Pentraxin 3 in atherosclerotic plaque reduces platelet thrombus formation under flow.
| Project/Area Number |
21790358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 循環器病理 / 血栓症 |
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| Research Abstract |
Atherosclerotic plaque disruption with subsequent thrombus formation is a major cause of atherothrombosis, particularly in acute myocardinal infarction. Inflammatory biomarkers play an important rule, in atherothrombosis. In this study, we investigate the role of PTX3, a novel imflammatory biomarker : in cardiovascular event. PTX3 was localized in coronary plaque, and the expression was significantly increased in patients with unstable angina. PTX3 inhibited platelet aggregation, and significantly reduced platelet thrombus formation under flow condition. Thus, PTX3 may affect thrombus formation via a platelet antagonist after plaque disruption.
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