2010 Fiscal Year Final Research Report
Analysis of pathogenic mechanism of pulmonary hypertension in patients with mixed connective tissue disease.
| Project/Area Number |
21790361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
KAMATAKI Akihisa Iwate Medical University, 医学部, 助教 (60360004)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 膠原病 / 自己抗体 / 肺高血圧症 |
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| Research Abstract |
Pulmonary hypertension (PH) is the major cause of death in patients with mixed connective tissue disease (MCTD). However, pathogenic mechanism of PH in MCTD is still unclear. Since pulmonary micro vascular endothelial cell injury is the first change on the development of PH, I focused on one of the serum factors, anti-endothelial cell antibodies (AECA), in this study. For identification of targets of AECA, two-dimensional electrophoresis, western blot analysis, and mass spectrometry were performed. I also constructed cDNA library of pulmonary micro vascular endothelial cell and performed serological identification of antigens by recombinant expression cloning (SEREX). As these results, possible antigens, including already-known antigens, were identified.
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[Journal Article] Analysis of pulmonary allergic vasculitis with eosinophil infiltration in asthma model of mice.
Author(s)
Yamauchi K, Sasaki N, Niisato M, Kamataki A, Shikanai T, Nakamura Y, Kobayashi H, Suwabe A, Kanno H, Sawai T, Inoue H.
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Journal Title
Exp Lung Res. 36(4)
Pages: 227-236
Peer Reviewed
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