2010 Fiscal Year Final Research Report
Functional analysis of molecular targeted therapy used human hepatocellular carcinoma proliferation and metastasis model
| Project/Area Number |
21790366
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
DU Wenlin Keio University, 医学部, 助教 (90348798)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 分子標的薬 / 肝細胞癌 |
|---|
| Research Abstract |
Multikinase inhibitor sorafenib is reported to have obtained a better effect than conventional chemotherapy for hepatocellular carcinoma. The influence and function of sorafenib on tumor invasion or metastasis is unknown. In this study, we aimed to analyze the mechanism of sorafenib on hepatocellular carcinoma (HCC) extension including tumor growth, invasion and metastasis and establish predictive model of sorafenib efficacy. Sorafenib inhibited the proliferation of HCC cell KYN2 more than Li7. Sorafenib also induced apoptosis on KYN2 not Li7. Sorafenib reduced the phosphorylation level of LYN on KYN2, but not on Li7. Microarray resulted the signal of LYN, FGFR4 of KYN2 were more than Li7. The difference expression of these tyrosinkinase molecular could be useful to find candidate biomarkers for prediction of sorafenib response.
|
