2010 Fiscal Year Final Research Report
Roles of HES1 and DEC2, newly identified transcriptional targets of GLI1, in pancreatic carcinogenesis.
| Project/Area Number |
21790370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
INAGUMA Shingo Aichi Medical University, 医学部, 講師 (80410786)
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| Project Period (FY) |
2009 – 2010
|
| Keywords | 分子病理 / 膵臓癌 / シグナル伝達 / ヘッジホッグ / 転写因子 |
|---|
| Research Abstract |
We identified DEC2 as one of the direct transcriptional targets of GLI1, a downstream transcription factor of Hedgehog signaling pathway, via CACCC-box-like elements localized between -1126 and -1117 in the DEC2 promoter. We also showed that one of the mismatch repair gene MLH1 was down-regulated by GLI1-induced DEC2. We propose the possibility that Shh-GLI1-DEC2 pathway represses MLH1 expression and could enhance gene alteration and genomic instability in pancreatic carcinogenesis.
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Research Products
(7 results)
