2010 Fiscal Year Final Research Report
Study of the molecular bases for the dynamics and dysfunction of dendritic cell subsets in tumor-bearing host
| Project/Area Number |
21790379
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UEHA Satoshi The University of Tokyo, 大学院・医学系研究科, 助教 (00447385)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 腫瘍 / 樹状細胞 / 癌 / ケモカイン |
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| Research Abstract |
We examined the tumor-infiltrating DC subsets with the potential to migrate to draining-lymph nodes and identified CCR7^+ MHC class II^<hi> TIDCs as the precursor of lymph node migratory DCs with antigen uptake and presentation potential. Chemokine receptor KO (CKO) mice and the wild type vs CKO mixed bone marrow chimera mice revealed that CCR2 partially mediates the accumulation of the TIDCs. We also found that the TIDCs were relatively resistant to the anti-cancer drug in vivo. Based on these results, we expect that the combination therapy of anti-cancer drug and CCR2 targeted drug that augment TIDCs would provide a novel anti-cancer immunotherapy.
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Research Products
(23 results)
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[Journal Article] Involvement of CD11b(+) GR-1 (low) cells in autoimmune disorder in MRL-Fas (lpr) mouse.2010
Author(s)
Iwata Y, Furuichi K, Kitagawa K, Hara A, Okumura T, Kokubo S, Shimizu K, Sakai N, Sagara A, Kurokawa Y, Ueha S, Matsushima K, Kaneko S, Wada T.
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Journal Title
Clin Exp Nephrol. 14
Pages: 411-417
Peer Reviewed
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[Journal Article] Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts.2010
Author(s)
Hoshino A, Iimura T, Ueha S, Hanada S, Maruoka Y, Mayahara M, Suzuki K, Imai T, Ito M, Manome Y, Yasuhara M, Kirino T, Yamaguchi A, Matsushima K, Yamamoto K.
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Journal Title
J Biol Chem. 285
Pages: 28826-28837
Peer Reviewed
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[Journal Article] Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells using a weak-based amphiphilic peptide.2010
Author(s)
Ikeuchi N, Futami J, Hosoi A, Noji S, Kurachi M, Ueha S, Fujii S, Yamada H, Matsushima K, Moriyasu F, Kakimi K.
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Journal Title
Biochem Biophys Res Commun. 392
Pages: 217-222
Peer Reviewed
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