• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Translational regulation of functional genes by microRNAs after HGF stimulation

Research Project

  • PDF
Project/Area Number 21790382
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionUniversity of Fukui

Principal Investigator

NAGANUMA Seiji  University of Fukui, 医学部, 助教 (50452123)

Project Period (FY) 2009 – 2010
Keywords食道癌 / 扁平上皮癌 / EMT / マイクロRNA / ZEB / HGF
Research Abstract

Epithelial-mesenchymal transition (EMT) of tumor cells promoted by stimulation of Hepatocyte growth factor (HGF) is regulated by some microRNAs (miR-200 family) via ZEB1 and ZEB2, and actually in esophageal cancer tissue, we clarified upregulation of ZEB, and downregulation of miR-200 family at the invasion front. Also, our data indicate that knockdown of ZEB prevents induction of EMT and cancer invasion as well, providing a novel mechanistic insight into esophageal carcinogenesis and tumor progression.

  • Research Products

    (5 results)

All 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus : miR-205 and miR-21 are specific markers for HNSCC and ESCC.2010

    • Author(s)
      Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K, Itoh H.
    • Journal Title

      Oncol Rep. 23(6)

      Pages: 1625-1633

    • Peer Reviewed
  • [Presentation] ZEB1 and ZEB2 promote tumor invasion and EMT in esophageal squamous cell carcinoma.2010

    • Author(s)
      長沼誠二, 大橋真也, 木村相泰, 夏井坂光輝, 中川裕, 伊藤浩史
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
  • [Presentation] ZEB1 and ZEB2 promote EMT and invasion in esophageal squamous cell carcinoma.2010

    • Author(s)
      Seiji Naganuma, Shinya Ohashi, Sotai Kimura, Mitsuteru Natsuizaka, Andres J.Klein-Szanto, Hiroshi Itoh, Hiroshi Nakagawa.
    • Organizer
      101st Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-04-19
  • [Presentation] High expression of microRNA-205 can be a possible biomarker of squamous epithelia : Application of miRNA extracted from formalin-fixed paraffin-embedded tissue by laser microdissection.2010

    • Author(s)
      Sotai Kimura, Seiji Naganuma, Dai Susuki, Kazuo Sano, Hiroshi Itoh.
    • Organizer
      101st Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-04-19
  • [Presentation] Expression of miR-200 family is associated with EMT (epithelial to mesenchymal transition) of esophageal squamous cell carcinoma.2009

    • Author(s)
      長沼誠二, 木村相泰, 鈴木弟, 伊藤浩史
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi