2010 Fiscal Year Final Research Report
Role of a new member of the NLR family in pathogen recognition and shaping adaptive immunity
| Project/Area Number |
21790386
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Osaka University |
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Principal Investigator |
KAWAI Taro Osaka University, 微生物病研究所, 准教授 (50456935)
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| Research Collaborator |
KUMAR Himanshu 大阪大学, 微生物病研究所, ポスドク研究員
TSUCHIDA Tetsuo 大阪大学, 微生物病研究所, 大学院生
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| Project Period (FY) |
2009 – 2010
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| Keywords | 自然免疫 / 感染 / シグナル伝達 / 炎症 / サイトカイン / アジュバント |
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| Research Abstract |
We analyzed roles of NLR-tb, a new member of the NLR family that we identified, in the regulation of innate immunity. We found that NLR-tb is capable of inducing the production of inflammatory cytokine IL-1beta. Furthermore, our analyses on NLR-tb-deficient mice suggested the possibility that NLR-tb responds to unknown pathogen components.
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