2010 Fiscal Year Final Research Report
The significance of macrophage in tumor microenveironment
| Project/Area Number |
21790388
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
KOMOHARA Yoshihiro Kumamoto University, 大学院・生命科学研究部, 助教 (40449921)
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| Project Period (FY) |
2009 – 2010
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| Keywords | マクロファージ |
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| Research Abstract |
In this study, we demonstrated the significance of macrophage in development of tumor microenvironment. We found that high infiltration of CD163- and CD204-positive M2 macrophages correlate to poor clinical prognosis in patients with glioma, cholangiocellular carcinoma, ovarian cancer, malignant lymphoma, and kidney cancer. By means of using murine cancer model, we showed that CD204 regulates the macrophage activation, differentiation to M2 phenotype, and promotes the tumor development. By analysis using human pathological specimens, we interestingly suggested the significant role of CD163 in development of tumor microenvironment.
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[Journal Article] Ratio of M2 macrophage expression in closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AILT).2010
Author(s)
Niino D, Komohara Y, Murayama T, Aoki R, Kimura Y, Hashikawa K, Kiyasu J, Takeuchi M, Seufuji N, Sugita Y, Takeya M, Ohshima K.
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Journal Title
Pathol Int 60
Pages: 278-283
Peer Reviewed
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