2010 Fiscal Year Final Research Report
Investigation into differentiation effect of TGF beta for cancer stem cells in bone-metastatic prostate cancer cells
| Project/Area Number |
21790390
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SATO Shinya Nagoya City University, 大学院・医学研究科, 助教 (30464564)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 前立腺癌 / 癌幹細胞 / 骨微小環境 / 分化誘導 / TGFbeta |
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| Research Abstract |
We raised the possibility of the existence of cancer stem cells in bone-metastatic prostate cancer cells. We also showed that prostate cancer cell proliferation was decreased by TGF beta1 receptor inhibitors in vivo and in vitro, and clarified the significance of TGF beta signaling regulation as a new prostate cancer therapy.
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Research Products
(7 results)
