2011 Fiscal Year Final Research Report
Development of brain tumor mouse models reflecting human counterparts
| Project/Area Number |
21790398
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
MOMOTA Hiroyuki 名古屋大学, 医学部附属病院, 病院助教 (60469971)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 癌 / 応用動物 / 病理学 / 脳神経疾患 / トランスレーショナルリサーチ |
|---|
| Research Abstract |
We have successfully established PDGFB-induced malignant glioma and Shh-induced medulloblastoma mouse models by using RCAS/tv-a system. These are the first brain tumor mouse models created by RCAS/tv-a system in Japan. We have also developed novel mouse models of medulloblastoma by using RCAS-p53 short hairpin or RCAS-c-Myc. A novel method of intracranial injection for brain tumor mouse models is invented by the support of this grant and has been published(J Neurosurg. 2012. 116 : 630-635).
|
Research Products
(31 results)
-
[Journal Article] The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma2011
Author(s)
Ohka F, Natsume A, Motomura K, Kishida Y, Kondo Y, Abe T, Nakasu Y, Namba H, Wakai K, Fukui T, Momota H, Iwami K, Kinjo S, Ito M, Fujii M, Wakabayashi T
-
Journal Title
PLoS One
Volume: Vol.6
Pages: 23332
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
