2011 Fiscal Year Final Research Report
The suppression of severe pathology during coinfection with Plasmodium berghei ANKA and Plasmodium berghei XAT
| Project/Area Number |
21790410
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Parasitology (including Sanitary zoology)
|
|---|
| Research Institution | Kyorin University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
KOBAYASHI Fumie 杏林大学, 医学部, 教授 (20118889)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | マラリア原虫 / 複合感染 / 病態重症化の抑制 / IL-10 |
|---|
| Research Abstract |
In this study, it is demonstrated that IL-10 Receptor(R)+cells and IL-10 play a crucial role for suppressing the severe pathology such as cerebral malaria during coinfection with Plasmodium berghei(Pb) ANKA and Pb XAT. It is seemed that IL-10R+cells and IL-10 were induced by the specific immune response against Pb XAT. In addition, the suppression of severe pathology during coinfection with Pb ANKA and Pb XAT was independent of spleen and Toll-like receptor.
|
