2010 Fiscal Year Final Research Report
Expression of CagA in polarized epithelial cells elicits forced mitogenesis
| Project/Area Number |
21790412
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Bacteriology (including Mycology)
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
KAMIYA Naoko The University of Tokyo, 大学院・医学系研究科, 助教 (40279352)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | ヘリコバクター・ピロリ / 胃がん / cagA遺伝子 / 上皮細胞極性 / 細胞増殖 |
|---|
| Research Abstract |
Infection with Helicobacter pylori cagA-positive strains is associated with gastric carcinoma. CagA-deregulated SHP2 elicits sustained Erk-MAPK activation. CagA also interacts and inhibits PAR1, resulting in induction of junctional and polarity defects. In polarized epithelial cells, CagA-driven Erk-MAPK signal prevents p21 expression by activating RhoA, thereby inducing forced mitogenesis.
|
Research Products
(14 results)
