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2010 Fiscal Year Final Research Report

Roles for intracellular innate immune receptors in host responses to Listeria monocytogenes infection

Research Project

  • PDF
Project/Area Number 21790416
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionKyoto University

Principal Investigator

TSUCHIYA Kohsuke  Kyoto University, 医学研究科, 助教 (50437216)

Project Period (FY) 2009 – 2010
Keywordsインフラマソーム / AIM2 / NLRP3 / ASC / リステリア / 細胞内寄生菌
Research Abstract

Listeria monocytogenes invades the cytoplasm of macrophages and induces the activation of caspase-1 and the subsequent maturation of IL-1β and IL-18. Although apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC), an adaptor protein of Nod-like receptors, has been shown to play an essential role in inducing this cellular response to L. monocytogenes, the mechanism has not been fully elucidated. In this study, we demonstrated that absent in melanoma 2 (AIM2), a cytosolic DNA receptor, plays an important role in the activation of caspase-1 during L. monocytogenes infection.

  • Research Products

    (12 results)

All 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages2010

    • Author(s)
      Sylvia Daim、河村伊久雄、土屋晃介, 他8名
    • Journal Title

      Journal of Medical Microbiology 60巻

      Pages: 5182-5191

    • Peer Reviewed
  • [Journal Article] PD-1-PDL-1 pathawy impairs Th1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guerin2010

    • Author(s)
      酒井俊祐、河村伊久雄、岡崎拓、土屋晃介, 他2名
    • Journal Title

      International Immunology 22巻

      Pages: 912-925

    • Peer Reviewed
  • [Journal Article] Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes2010

    • Author(s)
      土屋晃介、原英樹、河村伊久雄, 他7名
    • Journal Title

      The Journal of Immunology 185巻

      Pages: 1186-1195

    • Peer Reviewed
  • [Journal Article] Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages2010

    • Author(s)
      Yanna Shen、河村伊久雄、野村卓正、土屋晃介, 他7名
    • Journal Title

      nfection and Immunity 78巻

      Pages: 2857-2867

    • Peer Reviewed
  • [Journal Article] Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes2010

    • Author(s)
      Sita R.Dewamitta、野村卓正、河村伊久雄、原英樹、土屋晃介, 他8名
    • Journal Title

      Infection and Immunity 78巻

      Pages: 1884-1894

    • Peer Reviewed
  • [Journal Article] The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages2009

    • Author(s)
      暮沼武士、河村伊久雄、原英樹、内山良介、Daim S.、Dewamitta S.R.、井俊祐、土屋晃介, 他2名
    • Journal Title

      Infection and Immunity 77巻(有)

      Pages: 3992-4001

    • Peer Reviewed
  • [Presentation] Involvement of absent in melanoma 2 (AIM2) in inflammasome activation in macrophages infected with Listeria monocytogenes2010

    • Author(s)
      土屋晃介(筆頭演者)
    • Organizer
      The 10th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県・淡路市
    • Year and Date
      2010-09-08
  • [Presentation] Mechanism of inflammmasome activation upon infection with Listeria monocytogenes2010

    • Author(s)
      土屋晃介(筆頭演者)
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-08-25
  • [Presentation] Mechanism of inflammasome activation upon infection with Listeria monocytogenes2010

    • Author(s)
      土屋晃介(筆頭演者)
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      神奈川県・横浜市
    • Year and Date
      2010-03-27
  • [Presentation] Mechanism of the inflammasome activation upon infection with Listeria monocytogenes2009

    • Author(s)
      土屋晃介(筆頭演者)
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪府・大阪市
    • Year and Date
      2009-12-04
  • [Presentation] Mechanism of the inflammasome activation upon infection with Listeria monocytogenes2009

    • Author(s)
      土屋晃介(筆頭演者)
    • Organizer
      The 9th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県・淡路市
    • Year and Date
      2009-09-10
  • [Remarks] ホームページ等

    • URL

      http://www.med.kyoto-u.ac.jp/J/grad_school/introduction/1204/

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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