2010 Fiscal Year Final Research Report
Study of uncharacterized multidrug efflux pumps of Acinetobacter baumannii
| Project/Area Number |
21790432
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Matsuyama University |
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Principal Investigator |
SEKIYA Hiroshi Matsuyama University, 薬学部, 助教 (70454890)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アシネトバクター / 多剤排出ポンプ / 院内感染 / 多剤耐性菌 / 抗生物質 |
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| Research Abstract |
Multidrug efflux pumps plays an important role in the multidrug-resistant mechanism of gram-negative bacteria. In this study, I examined the role of multidrug efflux pumps with Acinetobacter baumannii, especially RND family multidrug efflux pumps. In the A. baumannii ATCC19798, eight gene clusters presumed to be RND type multidrug efflux pumps were found. It has been understood that the gene cluster including A1S 2304 presumed to be coding membrane fusion protein, A1S 2305 presumed to be coding RND type multidrug efflux protein and A1S 2306 presumed to be coding outer membrane protein takes part in the acriflavine resistance.
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