2011 Fiscal Year Final Research Report
Analysis of an inhibition mechanism of cell destruction in infected epithelial cells by Shigella
| Project/Area Number |
21790433
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ISHIHARA Tomoko 国立感染症研究所, 細菌第一部, 研究員 (30450555)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 感染症 / 微生物 / 細菌 |
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| Research Abstract |
Gram-negative pathogenic bacteria, such as Shigella secrete various virulence factors into a host cell for efficient and continuous infection. This research suggested that virulence factors have two opposite functions, which are to enhance or to inhibit destruction of an epithelial cell. They control rapid destruction of an infected cell by modifying the cell signal pathway. These results provide clues as to the underlying cause of enteric infection and is expected to contribute to infection control measures, such as treatment of infection and development of vaccine.
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[Journal Article] Molecular Subtyping in Cholera Outbreak, Lao People's Democratic Republic, 20102011
Author(s)
Sithivong N, Morita-Ishihara T, Vongdouangchanh A, Phouthavane T, Chomlasak K, Sisavath L, Khamphaphongphane B, Sengkeopraseuth B, Vongprachanh P, Keosavanh O, Southalack K, Jiyoung L, Tsuyuoka R, Ohinishi M, Izumiya H
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Journal Title
Emerging Infectious Diseases
Volume: 17
Pages: 2060-2062
DOI
Peer Reviewed
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