2010 Fiscal Year Final Research Report
Membrane-traffic of poliovirus-sensitive and insensitive cells
| Project/Area Number |
21790437
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | 財団法人微生物化学研究会 (2010)
The University of Tokyo (2009) |
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Principal Investigator |
NIHEI Coh-Ichi 財団法人微生物化学研究会, 微生物化学研究所, 研究員 (40373344)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ポリオウイルス / 膜輸送 / 感染 / ウイルス粒子 / 細胞透過 |
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| Research Abstract |
Poliovirus (PV) is known to be the causative agent of poliomyelitis. The productive infection of this virus is governed by a specific cell surface molecule that serves as the PV receptor (PVR). While the molecular mechanism of unproductive and PVR-independent blood-brain barrier (BBB) pathway is unclear.
We identified the transferrin receptor 1 (TfR1) of brain capillary endotherial cells as a binding protein to PV by using biochemical analysis and mass spectrography. Our data indicate that TfR1 is a receptor for PV BBB-permeation.
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