2010 Fiscal Year Final Research Report
Analysis of rac2 gene expression and its role on anti-HIV-1 restriction
| Project/Area Number |
21790450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Kinki University |
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Principal Investigator |
HAKATA Yoshiyuki Kinki University, 医学部, 助教 (30344500)
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| Project Period (FY) |
2009 – 2010
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| Keywords | HIV-1感染抵抗性遺伝子 |
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| Research Abstract |
Several genetic variations have been identified as factors which affect HIV-1 infection in human. We have recently discovered that human rac2 gene is one of the restriction genes for HIV-1 infection and individuals who possess high-expression type rac2 allele in their genome tend to be more resistant to HIV-1 infection as compared to people with low-expression type rac2 gene allele. During the term of this grant, we identified a single nucleotide polymorphism controlling Rac2 expression in an intron region of the rac2 gene. We found that Rac2 decreases CCR5 expression, a critical co-receptor for HIV-1 infection, at transcriptional level but increases CCL5 which binds to CCR5 and inhibits HIV-1 infection. These results suggest that higher Rac2 expression affects the HIV-1-cell interaction, leading to more resistant against HIV-1 infection.
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