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2010 Fiscal Year Final Research Report

Study for the mechanism of HIV-1-specific CTL induction in the intestinal mucosa

Research Project

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Project/Area Number 21790453
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

TERAHARA Kazutaka  National Institute of Infectious Diseases, 免疫部, 研究員 (50469954)

Project Period (FY) 2009 – 2010
Keywords感染防御 / ワクチン
Research Abstract

In this study, we aimed to elucidate the mechanism by which human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTLs) are induced in the intestine. HIV-1 Gag-expressing Salmonella typhimurium aroA- or aroA-invAmutants, which can or not, respectively, penetrate Peyer's patches, were used as oral antigens into mice. However, Gag-specific CTLs were hardly induced in both the systemic and the gut mucosal compartments. Further study should be needed for better understanding of the role of Peyer's patches in the induction of mucosal CTLs.

  • Research Products

    (13 results)

All 2011 2010 Other

All Journal Article (1 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.2011

    • Author(s)
      Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon M-N, Domino SE, Hiroi T, Yuki Y,Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H
    • Journal Title

      Biochem. Biophys.Res.Commun. 404

      Pages: 822-828

  • [Presentation] HIV-1 infection enhances the susceptibility of T cells to measles virus infection by upregulating signaling lymphocyte activation molecule (SLAM) expression.2011

    • Author(s)
      Mitsuki Y, Shibusawa K, Terahara K, Kobayashi K, Takeda M, Yanagi Y, Tsunetsugu-Yokota Y
    • Organizer
      Keystone Symposia
    • Place of Presentation
      British Columbia, Canada
    • Year and Date
      20110520-20110525
  • [Presentation] Inhibition of HIV-1 replication by short hairpin RNA is augmented by using lentivirus vector pseudotyped with envelope proteins of wild-type measles virus.2011

    • Author(s)
      Shibusawa K, Mitsuki Y, Terahara K, Ishige M, Yanagi Y, Kobayashi K, Tsunetsugu-Yokota Y
    • Organizer
      Keystone Symposia
    • Place of Presentation
      British Columbia, Canada
    • Year and Date
      20110520-20110525
  • [Presentation] 麻疹ウイルスエンベロープをもちいたHIV-1増殖抑制性レンチウイルスベクターの開発とその有効性2010

    • Author(s)
      渋沢謙太郎、光木裕也、寺原和孝、石毛真行、柳雄介、小林和夫、横田(恒次)恭子
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      20101107-20101109
  • [Presentation] HIV-1感染モデルとしてのヒト化マウスの妥当性とX4およびR5HIV-1感染2010

    • Author(s)
      石毛真行、寺原和孝、光木裕也、渋沢謙太郎、小林和夫、岡田誠治、横田(恒次)恭子
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      20101107-20101109
  • [Presentation] Inhibition of HIV-1 replication by envelope-engineered lentivirus vectors : efficient gene delivery using envelope protein of measles virus.2010

    • Author(s)
      Shibusawa K, Mitsuki Y, Terahara K, Ishige M, Yanagi Y, Kobayashi K, Tsunetsugu-Yokota Y
    • Organizer
      The 10th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Japan
    • Year and Date
      20100907-20100910
  • [Presentation] Inhibition of HIV-1 replication by engineered lentivirus vectors : a potential advantage of SLAM-mediated virus entry.2010

    • Author(s)
      Shibusawa K, Mitsuki Y, Terahara K, Yanagi Y, Kobayashi K, Tsunetsugu-Yokota Y
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20100822-20100827
  • [Presentation] HIV-1 infection enhances the susceptibility of T cells to measles virus infection by upregulating signaling lymphocyte activation molecule (SLAM) expression.2010

    • Author(s)
      Mitsuki Y, Shibusawa K, Terahara K, Kobayashi K, Takeda M, Yanagi Y, Tsunetsugu-Yokota Y
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20100822-20100827
  • [Presentation] Characteristic activation/differentiation phenotype of CD4^+ T cells and their distinct susceptibility to X4-type and/or R5-type HIV-1 infection in humanized NOD/SCID/Jac3-null mice.2010

    • Author(s)
      Terahara K, Ishige M, Mitsuki Y, Shibusawa K, Watanabe S, Okada S, Kobayashi K, Tsunetsugu-Yokota Y
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20100822-20100827
  • [Presentation] Factors crucial for the preferential propagation of R5-tropic HIV-1 in the early phase of HIV-1 infection.2010

    • Author(s)
      Tsunetsugu-Yokota Y, Terahara K
    • Organizer
      The 5th German-Japanese Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20100509-20100512
  • [Presentation] HIV-1 infection enhances the susceptibility of T cells to measles virus infection by upregulating signaling lymphocyte activation molecule (SLAM) expression.2010

    • Author(s)
      Mitsuki Y, Shibusawa K, Terahara K, Kobayashi K, Takeda M, Yanagi Y, Tsunetsugu-Yokota Y
    • Organizer
      The 5th German-Japanese Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20100509-20100512
  • [Presentation] Inhibition of HIV-1 replication by engineered lentivirus vectors : a potential advantage of SLAM-mediated virus entry.2010

    • Author(s)
      Shibusawa K, Mitsuki Y, Terahara K, Yanagi Y, Kobayashi K, Tsunetsugu-Yokota Y
    • Organizer
      The 5th German-Japanese Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20100509-20100512
  • [Remarks] ホームページ等

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Published: 2012-02-13   Modified: 2016-04-21  

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