2010 Fiscal Year Final Research Report
Identification and Characterization of the second receptor of Enterovirus 71
| Project/Area Number |
21790454
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | 財団法人東京都医学研究機構 (2010)
Tokyo Metropolitan Organization for Medical Research (2009) |
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Principal Investigator |
YAMAYOSHI Seiya 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (50529534)
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| Project Period (FY) |
2009 – 2010
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| Keywords | エンテロウイルス71 / レセプター / 手足口病 |
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| Research Abstract |
We established Enterovirus 71 (EV71)-sensitive mouse L929 cells (Ltr246 cells), which carried a portion of human genomic DNA. To identify the second receptor of EV71, we analyzed the expression of mRNA in Ltr246 cells, comprehensively. Although three human genes (TSN, CCL2 and MEPCP) were integrated into Ltr246 cell genome, these were not related to EV71 sensitivity of Ltr246 cells.
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