2010 Fiscal Year Final Research Report
A novel molecule that regulates T-cell tolerance under PD-1.
| Project/Area Number |
21790465
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
CHIKUMA Shunsuke Kyoto University, 医学研究科, 助教 (50437208)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 免疫寛容 / 自己免疫 / 免疫抑制受容体 |
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| Research Abstract |
ITAG-1 was first identified as a novel molecule that was uniquely suppressed by PD-1 mediated inhibitory signal in T-cells. Analyses using newly generated ITAG-1 knockout mice revealed ITAG-1's role in the terminal development of cytotoxic T-cells. Although, the precise mechanism is still under investigation, current data suggested PD-1 mediated modulation of ITAG-1 expression is involved in T cell activation, differentiation and tolerance.
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