2010 Fiscal Year Final Research Report
Aryl hydrocarbon receptor regulates innate and acquired immune resposes
| Project/Area Number |
21790468
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Keio University (2010)
Osaka University (2009) |
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Principal Investigator |
KIMURA Akihiro Keio University, 医学部, 助教 (20533318)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Ahr / LPS / マクロファージ / 関節リウマチ / 自然免疫 |
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| Research Abstract |
Ahr is induced in macrophages stimulated by LPS. The production of IL-6 and tumor necrosis factor (TNF)-α by LPS was significantly elevated in Ahr-deficient macrophages compared to that in wild-type (WT) cells. Ahr forms a complex with Stat1 and nuclear factor-kappa B (NF-κB) in macrophages stimulated by LPS, which leads to inhibition of the promoter activity of IL-6. Ahr thus plays an essential role in the negative regulation of the LPS signaling pathway through interaction with Stat1. In dendritic cells, Ahr induces the expression of IDO, which promotes Treg cell differentiation.
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[Journal Article] SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling.2011
Author(s)
Hashimoto M, Hiwatashi K, Ichiyama K, Morita R, Sekiya T, Kimura A, Sugiyama Y, Sibata T, Kuroda K, Takahashi R, Yoshimura A.
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Journal Title
Int Immunol 23
Pages: 165-176
Peer Reviewed
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[Journal Article] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells.2011
Author(s)
Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T.
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Journal Title
J Immunol 186
Pages: 32-40
Peer Reviewed
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