2010 Fiscal Year Final Research Report
Studies on function of IL-27 and the related cytokines on regulation of inflammation and the clinical application.
| Project/Area Number |
21790474
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyushu University (2010)
Saga University (2009) |
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Principal Investigator |
MIYAZAKI Yoshiyuki Kyushu University, 大学院・農学研究院, 学術共同研究者 (40380779)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アレルギー・ぜんそく / 炎症 / 感染症 / サイトカイン / 免疫学 |
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| Research Abstract |
IL-27 is a cytokine composed of two subunit proteins (EBI-3 and p28), and plays important roles in maturation of helper T lymphocytes and inhibition of inflammation. In this study, we performed an animal model experiment for delayed type hypersensitivity (DTH), and revealed that IL-27 acts in amelioration of DTH. Furthermore, we proved that IL-27 suppresses terrible inflammation developed in infection of protozoan parasites, viruses and bacteria. We suggested that IL-27 weaken the inflammatory responses by inhibiting production of an inflammatory cytokine IL-17.
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