2010 Fiscal Year Final Research Report
Analysis of the molecular mechanism of the mTOR-mediated IL-10 expression in dendritic cells
| Project/Area Number |
21790481
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
OHTANI Masashi Kansai Medical University, 医学部, 助教 (20383713)
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| Project Period (FY) |
2009 – 2010
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| Keywords | mTOR / IL-10 / サイトカイン / 樹状細胞 |
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| Research Abstract |
The overexpression of eIF4E, a downstream molecule of mTOR, enhanced IL-10 production in mouse dendritic cells, whereas the inhibition of eIF4E by inhibitor suppressed IL-10 production. The mTOR inhibitor did not influence the expression of Sp1 and c-Fos and the IFN-ss -mediated IL-10 regulation through an autocrine action. These results suggest that mTOR positively regulates LPS-induced IL-10 expression through eIF4E, although not Sp1 and c-Fos, IFN-ss, which are positive regulator of IL-10.
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