Analysis for the mechanism of inducing the autoimmune-like diseases in the Ste20-like kinase Mst1 deficient mice.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790482
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Kansai Medical University
• Principal Investigator: UEDA Yoshihiro Kansai Medical University, 医学部, 講師 (90533208)
• Project Period (FY): 2009 – 2010
• Keywords: 自己免疫 / インテグリン / Mst1 / リンパ強雨の分化 / リンパ球動態 / 接着

Research Abstract

Mst1 deficient mice exhibited autoimmune phenotypes such as leukocyte infiltration in multiple tissues as well as the production of autoantibody. Indeed, Mst1 deficiency caused impaired the thymocyte selection in the TCR transgenic models as well as the generation of Treg in the thymus. Observation of thymocyte dynamcis on the thymic slice by 2-photon microscope revealed the defective thymocyte migration in the cortex and medulla. Our observations suggest the novel roles for Mst1 in the regulation of self-tolerance.

Research Products

• [Journal Article] RAPL deficiency caused lymphoproliferative disorders through the mislocalization of p27^<kip>. (2011)
  • Author(s): Katagiri, K., Ueda, Y., Tomiyama, T., Yasuda, K., Toda, Y., Ikehara, S., Nakayama, K.I, Kinashi, T.
  • Journal Title: Immunity 34(1) Pages: 24-38
  • Peer Reviewed
• [Journal Article] Rapl controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and-independent manners. (2010)
  • Author(s): Ebisuno, Y., Katagiri, K., Katakai, T., Ueda, Y., Nemoto, T., Inada, H., Nabekura, J., Okada, T., Kannagi, R., Tanaka, T., Miyasaka, M., Hogg, N., Kinashi, T.
  • Journal Title: Blood 115(4) Pages: 804-814
  • Peer Reviewed
• [Journal Article] Mstl controls lymphocyte trafficking and interstitial motility within lymph nodes. (2009)
  • Author(s): Katagiri K, Katakai T, Ebisuno Y, Ueda Y, Okada T, Kinashi T.
  • Journal Title: EMBO J. 26(9) Pages: 1319-1331
  • Peer Reviewed
• [Presentation] Department of Molecular Genetics, Kansai Medical University, Osaka, Japan. (2010)
  • Author(s): Tatsuo Kinashi, Koko Katagiri, Katakai Tomoya, Yoshihiro Ueda, Katsuyoshi Habiro
  • Organizer: 「Crucial roles of Mstl and RAPL (RASSF5b) in lymphocyte adhesion and proliferation」The second workshop on the HIPPO tumor suppressor pathway
  • Place of Presentation: Rome, Italy
  • Year and Date: 20101102-20101105
• [Presentation] The Ste20-like kinase Mstl is essential for maintenance of T cell homeostasis and immunological tolerance. (2010)
  • Author(s): Y.Ueda, K.Katagiri, K.Yasuda, T, Tomiyama, K.Habiro, T.Katakai, S.Ikehara, T.Kinashi
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe,神戸国際会議場
  • Year and Date: 20100823-20100827
• [Presentation] Roles for Mstl kinase in T cell homeostasis and autoimmune diseases (2009)
  • Author(s): 植田祥啓
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪,大阪国際会議場
  • Year and Date: 20091202-20091204