2011 Fiscal Year Final Research Report
Analysis of immunological synapse in physiological condition
| Project/Area Number |
21790486
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TANE Akiko (橋本 彰子) 独立行政法人理化学研究所, 免疫シグナル研究グループ, 研究員 (10415226)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 免疫シナプス / T 細胞抗原受容体 / 蛍光イメージング / 細胞骨格 |
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| Research Abstract |
When T cells recognize antigen on antigen.presenting cells, they start adhere and generate T cell antigen receptors (TCR) microclusters (TCR-MCs) which is a unit for starting T cell activation. The TCR-MCs move toward the center of the interface and form immunological synapse. We revealed and published that the transportation of TCR-MCs depends on microtubule motor, dynein and negatively regulate T cell activation. These observation were based on the quantitative analysis of TCR-MCs generated under physiological stimulus conditions.
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[Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation2010
Author(s)
Yokosuka, T, Kobayashi, W, Takamatsu, M, Sakata-Sogawa, K, Zeng, H, Hashimoto-Tane, A, Yagita, H, Tokunaga, M, Saito, T
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Journal Title
Immunity
Volume: 33(3)
Pages: 326-339
Peer Reviewed
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