2011 Fiscal Year Final Research Report
Analysis of the pathogenic mechanisms of autoimmune diseases induced by overproduction of cytokine TSLP
| Project/Area Number |
21790488
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
ISEKI Masanori 独立行政法人国立国際医療研究センター, 免疫制御研究部, 免疫応答修飾研究室長 (30532353)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アレルギー・免疫関連疾患 / 自己免疫疾患 / サイトカイン / マウスモデル |
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| Research Abstract |
It has been known that the cytokine thymic stromal lymphopoietin(TSLP) promotes the differentiation of type 2 helper T cells(Th2 cells) and induces allergic inflammations including asthma and atopic dermatitis. However, the details of its pathogenic mechanisms were still remained unclear. In this research, we found that TSLP directly stimulates CD4^+T cells and induces Th2 condition in vivo, which leads to polyclonal B cell activation and the autoimmune disease. These results would be applied to the development of novel therapies for immune diseases.
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