2010 Fiscal Year Final Research Report
Molecular mechanisms involved in human transplacental transport of anionic drug
| Project/Area Number |
21790518
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATOH Hiroki The University of Tokyo, 大学院・薬学系研究科, 助教 (80451855)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 薬物胎盤透過 / アニオン性薬物 / トランスポーター / 非ステロイド性消炎鎮痛薬 / トロホブラスト細胞 |
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| Research Abstract |
The transport of nonsteroidal anti-inflammatory drugs (NSAIDs) in trophoblast cells isolated from human placenta was suggested to be mediated by carrier(s), and be attributed, at least in part, to monocarboxylate transporter (MCTs). The transcellular transport of NSAIDs was examined by using isolated trophoblast cells for the first time. The present experimental system is suggested to be a potential tool to easily predict the transplacental transport of drugs in vitro.
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