2011 Fiscal Year Final Research Report
Pathological mechanism for interferon-induced depression
Project/Area Number |
21790529
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Applied pharmacology
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
YAMANAKA Hajime 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, リサーチアソシエイト (10415573)
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Project Period (FY) |
2009 – 2011
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Keywords | PETイメージング / 霊長類 / 活動量 / セロトニンレセプター / セロトニントランスポーター |
Research Abstract |
In order to evaluate interferon-induced changes in locomotor activity and serotonergic nervous system, we established evaluating system containing both activity monitoring system using video and positron emission tomography(PET) imaging of two proteins related to serotonergic neurotransimission. We clarified temporal changes in total duration of normal activity as well as distributions of two PET tracer accumulations in monkey brain. In addition, effect of anesthetized state on the PET imaging was investigated.
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[Journal Article] An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys : In vivo Positron Emission Tomography Imaging of Glial Activation2012
Author(s)
Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, Ji B, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H
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Journal Title
PLoS One
Volume: 7
Pages: e30526
Peer Reviewed
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[Journal Article] Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids2011
Author(s)
Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergstrom M, Onoe H, Langstrom B, Watanabe Y
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Journal Title
PET study with[^<11> C] vorozole. Neuroreport
Volume: 22
Pages: 326-330
Peer Reviewed
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[Journal Article] Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model2011
Author(s)
Ito Y, Shimazawa M, Inokuchi Y, Yamanaka H, Tsuruma K, Imamura K, Onoe H, Watanabe Y, Aihara M, Araie M, Hara H
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Journal Title
Eur J Neurosci
Volume: 33
Pages: 843-855
Peer Reviewed
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[Journal Article] Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates : PET study with R-^<11> C-verapamil and 11C-oseltamivir2011
Author(s)
Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y
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Journal Title
J Nucl
Volume: 52
Pages: 950-957
Peer Reviewed
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[Presentation] C^^<11>-Labeled cetrozole : a better PET tracer for aromatase2009
Author(s)
Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X. L., Wada, Y., Takashima, T., Katayama, Y., Yamanaka, H., Suzuki, M., Onoe, H., Watanabe, Y.
Organizer
World Molecular Imaging Congress
Place of Presentation
Montreal
Year and Date
2009-09-24
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