2011 Fiscal Year Final Research Report

Identification of novel transporter genes involved in transport of nucleotide anticancer drugs

Research Project

Project/Area Number	21790530
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Applied pharmacology
Research Institution	University of Niigata Prefecture
Principal Investigator	KAMLYAMA Shin 新潟県立大学, 人間生活学部, 助教 (70525401)
Project Period (FY)	2009 – 2011
Keywords	輸送体 / SLC35 / 抗癌剤耐性 / 癌 / 増殖
Research Abstract	SLC35F transporter family contains 6 member genes of unknownfunction. This study aimed to determine whether these genes are involved in sensitivity of cancer cells to nucleotide anticancer drugs. Silencing of these genes decreased cell growth of colon cancer cells ; however, that did not affect the sensitivity to 5fluorouracil. These results indicate that SLC35F members have no function on transport of nucleotide anticancer drugs in cancer cells.