2010 Fiscal Year Final Research Report
Identification of microRNAs regulating apoptosis and elucidation of their role in carcinogenesis.
| Project/Area Number |
21790533
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka University |
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Principal Investigator |
TATSUMI Naoya Osaka University, 大学院・医学系研究科, 寄附講座助教 (60512960)
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| Project Period (FY) |
2009 – 2010
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| Keywords | microRNA / WT1遺伝子 / アポトーシス / 癌 |
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| Research Abstract |
We found that the expression of WT1 was suppressed in Doxorubicin (Dox)-induced apoptosis in a concentration-dependent manner. Cloning of small RNAs expressed in DOX-treated gastric cancer cells revealed twenty-two miRNAs that increased in their expression levels during this process. Among them, we identified miR-A as a miRNA that could target WT1 and regulate apoptosis. Moreover, we showed that the expression of miR-A could be a prognostic factor for non-small cell lung cancers.
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