2011 Fiscal Year Final Research Report
Molecular epidemiological study on the causative agent of cat scratch disease, Bartonella henselae
Project/Area Number |
21790538
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Laboratory medicine
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Research Institution | Yamaguchi University |
Principal Investigator |
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Project Period (FY) |
2009 – 2011
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Keywords | 猫ひっかき病 / Cat scratch disease / Bartonella henselae / Multilocus sequencetyping(MLST) / Multispacer typing(MST) / virB5 / bepA / badA |
Research Abstract |
Bartonella henselae is the causative agent of cat scratch disease(CSD). We characterized B. henselae isolates from CSD patients and cats using DNA sequence-based genotyping methods. Our study demonstrated that human infections in Japan can be caused by B. henselae strains in MST cluster 1, distinct from clusters containing the Houston-1 and Marseille type strains. Furthermore, we developed a novel genotyping method based on three virulence genes(virB5, bepA and badA), and uncovered the genotypic distribution of B. henselae in Japan.
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Research Products
(17 results)
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[Journal Article] Molecular typing of Bartonella henselae DNA extracted from human clinical specimens and cat isolates in Japan2010
Author(s)
Yanagihara M, Tsuneoka H, Hoshide S, Ishido E, Umeda A, Tsukahara M, Nojima J, Ichihara K, Hino K, Hirai I, Yamamoto Y
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Journal Title
FEMS Immunology and Medical Microbiology
Volume: 60
Pages: 44-48
Peer Reviewed
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