2010 Fiscal Year Final Research Report
Glycan ligands of killer lectin-like receptors and regulation of NK functions
| Project/Area Number |
21790544
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Toho University |
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Principal Investigator |
HIGAI Koji Toho University, 薬学部, 講師 (70297711)
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| Project Period (FY) |
2009 – 2010
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| Keywords | NK細胞 / Killer LRs / NCRs / sialyl Lewis X |
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| Research Abstract |
Using recombinant extracellular lectin-like domains of KLRs (rKLRs) and NCRs (rNCRs) on NK cells, we evaluated their ligands specificity and binding affinities. Our data resulted that rKLRs and rNCRs can bind to sialyl Lewis X, GAGs and sulfated polysaccharides.
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