2010 Fiscal Year Final Research Report
The analysis of differentiative pathway in neutrophils using in vitro model and the pathogenic mechanisms of progression to leukemia
| Project/Area Number |
21790546
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
TSUJIOKA Takayuki Kawasaki Medical School, 医学部, 講師 (50330551)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Syk / 好中球 / 分化 / G-CSFレセプター |
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| Research Abstract |
The tyrosine kinase Syk (molecular weight 72KDa) which is widely expressed in hematopoietic and non-hematopoietic cells has been reported as a key molecule which is associated with hematopoiesis of the B cell lineage. We noticed the role of Syk in leukemic progression of myeloid lineage and established the differentiative model in neutrophil and Syk mutant cell lines using 32D (mouse AML cell lines). As a result, we suggested that Syk was not associated with the differentiation of myeloid lineage, but high expression of Syk SH2 domain was related to the suppression of differentiation.
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