2010 Fiscal Year Final Research Report
Analysis of a potential target at SCD-1, catalytic enzyme of fatty acid, for the prevention of cardiovascular disease.
| Project/Area Number |
21790548
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Gunma University |
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Principal Investigator |
MATSUI Hiroki Gunma University, 医学部, 助教 (20431710)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 循環器・高血圧 / 脂質 / メタボリックシンドローム / 予防医学 |
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| Research Abstract |
To evaluate the effect of high plasma levels of free fatty acid, which are observed in the patients with obesity or diabetes, and catalytic enzyme of fatty acid on the onset of cardiovascular disease, we examined several basic analyses. As a result, we identified that saturated-fatty acids adversely affect the cardiovascular disease, and stearoyl-coA desaturase-1 (SCD-1), a catalytic enzyme which converts saturated fatty acids to monounsaturated fatty acids, has a protective role against saturated-fatty acids-induced these effects. In conclusions, our results demonstrated that SCD-1 as the novel preventive and therapeutic target for cardiovascular disease in obese or diabetic patients.
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