2011 Fiscal Year Final Research Report
Association of genetic polymorphisms in human NR1I3 with the diseases in elderly Japanese population.
| Project/Area Number |
21790549
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IKEDA Shinobu 東京医科歯科大学, 難治疾患研究所, 助教 (20415508)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子遺伝疫学・フェノームスキャン研究 |
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| Research Abstract |
In this study, we performed search for genotype-phenotype associations in consecutive autopsies of elderly Japanese population, focusing on human CAR polymorphisms and various diseases. We found that several SNPs in NR1I3 gene were significantly associated with reduce or increase risk of the diseases, after adjustment. We provide data that polymorphisms of CAR, which controls the metabolism and elimination of endogenous and exogenous toxic compound or drugs, may play an important role in the development of the diseases. However, further prospective studies with large sample sizes are required to confirm our observations.
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