2010 Fiscal Year Final Research Report
Basic study for clinical application of the biomarkers for insecticide exposure
| Project/Area Number |
21790551
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
UEYAMA Jun Nagoya University, 医学部・保健学科, 助教 (00397465)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 農薬 / 殺虫剤 / バイオモニタリング |
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| Research Abstract |
Urinary pyrethroid (PYR) metabolites, e.g. 3-phenoxybenzoic acid (3-PBA), and organophosphorus insecticide (OP) metabolites, e.g. dialkylphosphate (DAP), have been used as the most sensitive biomarker for environmental PYR and OP exposure since the late 1990s. The objective is to clarify the fundamental characteristics of urinary OP and PYR metabolite for the practical usage. Our study had three major findings. First, the most salient findings are the distribution of urinary DAP concentrations in Japanese non- and occupational OP exposure workers, suggesting that the urinary DAP concentrations in Japanese workers were approximately at the same or lower levels than those in other countries. Second, there was seasonal differences of urinary DAP concentrations (summer > winter). Third, PYR metabolite, 3-PBA, excretion was decreased by co-exposure of OP due to part in carboxylesterase inhibition.
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Research Products
(15 results)
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[Presentation] 浜島信之非喫煙成人女性での尿中コチニン値と受動喫煙との関連2010
Author(s)
喜田優人, 近藤高明, 田中哲也, 中川優子, 木下香織, 鈴木麻予, 服部由花, 一ノ谷英憲, 木全明子, 上山純, 森田えみ, 田村高志, 栗木砂家加, 冨田耕太郎, 岡田理恵子, 川合紗世, 菱田朝陽, 内藤真理子, 若井建志
Organizer
第56回東海公衆衛生学会学術大会
Place of Presentation
岐阜県岐阜市
Year and Date
2010-07-24
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