2010 Fiscal Year Final Research Report
The prevention of the metabolic syndrome and the non-alcoholic fatty liver in the Japanese
| Project/Area Number |
21790553
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Shimane University |
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Principal Investigator |
YAMASAKI Masayuki Shimane University, 医学部, 助教 (60379683)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 予防医学 |
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| Research Abstract |
This study evaluated the physiologic properties of high carbohydrate diet and high fat diet (low carbohydrate diet) by examining its effects on body fat and fatty liver in mice. Mice were fed three experimental diets that were high carbohydrate diet, high fat diet and normal diet. The high carbohydrate and high fat groups were tendencies to increase body weight than normal group. In analysis of gene expressions for the lipid metabolism enzymes and its regulator, de novo lipogenesis in liver of the high carbohydrate group with onset of fatty liver was activated. In further study, Future studies are required to investigate the fatty liver onset by the high carbohydrate diet gives to obesity.
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