2011 Fiscal Year Final Research Report
Elucidation of the mechanism of developing cardiovascular disease by job stress : a multi-biomarker assessment.
| Project/Area Number |
21790561
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 職業性ストレス / 動脈硬化 / バイオマーカー |
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| Research Abstract |
The purpose of the present research was to elucidate the mechanisms by which job stress increases the risk of cardiovascular disease, by asking job stress and by measuring several biochemical markers and brachial artery stiffness indices as physiological markers in 2 workplaces. There was a significant negative correlation between N-terminal pro B type natriuretic peptide(NT-proBNP), a marker of cardiac stress, and job control. In addition, the volume elastic modulus(VE), a marker of brachial artery stiffness, was significantly correlated with "I feel anger.""I am irritating on the inside.", and "I cannot do any work." among the questions about the psychosomatic state during working. These results raise the possibility that job stress increases cardiac stress and impairs brachial artery properties. The measurement of NT-proBNP and VE may also be useful for evaluating cardiovascular risk caused by job stress.
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