2010 Fiscal Year Final Research Report
Development of novel phage antibody libraries for preparation of anti-drug antibodies
| Project/Area Number |
21790610
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
SASAO Ako Kumamoto University, 大学院・生命科学研究部, 助教 (80284751)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 社会医学 / 抗薬物抗体 / 法医中毒学 / 組換え抗体 |
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| Research Abstract |
The aim of this study was to develop phage antibody libraries to facilitate anti-drug antibodies preparation. The hybridoma that produces anti-fluvoxamine (FLV ; antidepressant) antibodies was used for analysis of the epitope sequence. And also, plasmid vector to produce the anti-FLV single chain variable fragment (scFv) was prepared. The hybridoma that produces anti-phenothiazines (antipsychotic) antibodies was also prepared.
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